Why is Yeast Glucan an Immunomodulator?

What is Yeast Derived Beta Glucan?

Yeast glucan is commonly derived from baker's yeast or brewer's yeast. Although both are beta 1,3/1,6 glucans from Saccharomyces Cerevisiae, the source is extremely important, beta-glucans from baker's yeast cell walls have different molecular patterns than brewer's yeast and can affect the immune-modulating capacity of the finished product. Research supports the immunomodulatory properties of baker's yeast beta-glucan, however, not all strains are the same.

What are the Differences between Beta Glucans from 3 sources?

Cereal grains, mushrooms, and yeast. It sounds like a grocery list for a restaurant. All these ingredients have in common that they are sources of beta-glucans. Nevertheless, the similarities end there. Not only do the three types differ on a molecular level, but they also differ in how they affect the body. While each of these types of beta-glucan may have health benefits, its benefits vary by type of beta-glucan.

How to Produce Qualified Yeast Beta Glucan?

When selecting yeast beta-glucans for immune health, the manufacturers should focus on the quality of such beta-glucan. Basically, it boils down to three factors: mechanism of action, extraction process, and consistency in the production process.

★ Mechanism of Action: High-grade beta-glucans are supported by an in-depth understanding of the biological activity of the ingredients and their mechanism of action in the body. Each source of beta-glucan has a different structure (molecular backbone and branching level), which affects its biological activity. For example, take baker's yeast beta-glucan, which is extracted from yeast cell walls. Certain clinical studies have shown that yeast-derived beta-glucans have immunity-enhancing properties.

★ Extraction process: The manufacturing or processing method used to extract yeast beta-glucan can affect its structure. If the structure of such beta-glucan is damaged or altered during the manufacturing process, the result can be a loss of certain immune health benefits in the final product.

★ Consistency in the Production Process: To ensure ingredients are stable and perform well, manufacturers must determine and ensure product serving size, manufacturing consistency, and stability.

Why is Yeast Glucan an immunomodulator?

Research over the last decade supports that some yeast beta-glucans can provide an effective training stimulus for the immune system. A recent review of clinical studies suggests that yeast beta-glucan may be an immunomodulator that trains the body's immune cells to respond faster when a pathogen is detected. This newly discovered phenomenon occurs when innate immune cells encounter specific microbes (live or not), causing the cells to respond more effectively to future threats. Essentially, this means that after experiencing one of these training stimuli, innate immune cells retain a "memory" of that experience, which allows them to respond faster and more efficiently when they encounter another pathogen.

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